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But a chemical’s safety when it’s used externally is not always the same as when it’s ingested. Different uses of the same ingredient may cause very different health outcomes.

We've measured many different immunological markers, both in the mucosa of the intestine and the lymphoid organs part of the intestine and we didn't see any inflammation there or changes in white blood cell number, Kaminski said. They also looked at the spleen where titanium dioxide was taken up into the bloodstream. You would expect [titanium dioxide] would be filtered out in the spleen and maybe induce inflammation there, but we did not see that, Kaminski added.

Neutral White, 26 per cent zinc sulphide, 66 per cent barium sulphate, 5 per cent infusorial earth, 3 per cent whiting.

CSPI says it might reconsider its rating if specifications for food-grade titanium dioxide in the U.S. are updated to ensure nanoparticles are minimized, and new studies are conducted to assess its capacity to cause cancer or other health problems. 

The aim of this work was to examine particularly the Degussa P25 titanium dioxide nanoparticles (P25TiO₂NPs) because they are among the most employed ones in cosmetics. In fact, all kinds of titanium dioxide nanoparticles (TiO₂NPs) have gained widespread commercialization over recent decades. This white pigment (TiO₂NPs) is used in a broad range of applications, including food, personal care products (toothpaste, lotions, sunscreens, face creams), drugs, plastics, ceramics, and paints. The original source is abundant in Earth as a chemically inert amphoteric oxide, which is thermally stable, corrosion-resistant, and water-insoluble. This oxide is found in three different forms: rutile (the most stable and substantial form), brookite (rhombohedral), and anatase (tetragonal as rutile), of these, both rutile and anatase are of significant commercial importance in a wide range of applications [3]. Additionally, the nano-sized oxide exhibits interesting physical properties, one of them is the ability to act as semiconducting material under UV exposure. In fact, TiO₂NPs are the most well-known and useful photocatalytic material, because of their relatively low price and photo-stability [4]. Although, this photoactivity could also cause undesired molecular damage in biological tissues and needs to be urgently assessed, due to their worldwide use. However, not all nanosized titanium dioxide have the same behavior. In 2007, Rampaul A and Parkin I questioned: “whether the anatase/rutile crystal form of titanium dioxide with an organosilane or dimethicone coat, a common titania type identified in sunscreens, is appropriate to use in sunscreen lotions” [5]. They also suggested that with further study, other types of functionalized titanium dioxide could potentially be safer alternatives. Later, Damiani found that the anatase form of TiO₂NPs was the more photoactive one, and stated that it should be avoided for sunscreen formulations, in agreement with Barker and Branch (2008) [6,7].

Market Dynamics

Matthew Wright, chair of the authority's working group on titanium dioxide, noted that the evidence for general toxic effects was not conclusive, but that the panel couldn't rule out genotoxicity entirely. There were also some current data limitations and the assessment could not establish a safe level for daily intake of the food additive, he stated.

Hiding power

EFSA's evaluation is related to the risks of TiO₂ used as a food additive, not to other uses.

Stability and darkening:

In sunscreen, titanium dioxide is used as a barrier to keep the sun's ultraviolet (UV) rays from damaging your skin. It's processed into much smaller particles than what goes into food, called nanoparticles. In this form, it becomes transparent, and also absorbs UV light so it doesn't reach your skin.

Background

We’re most often exposed to E171 through the foods we ingest. We find E171 in many food products, like popsicles, ice cream, gum, and more. Another way we ingest E171 is through pharmaceutical drugs. Many pills and capsules contain E171 as an inactive ingredient.  

Titanium dioxide (TiO2) is a versatile and widely used inorganic compound that has numerous applications, ranging from pigments in paints and coatings to cosmetics and pharmaceuticals. As a result, the demand for TiO2 powder suppliers has been steadily increasing.